Spencer,2,3 Chad J. Creighton,3 Michael M. The role of Notch signaling in the maintenance of adult murine prostate epithelial homeostasis remains unclear. We found that Notch ligands are mainly expressed within the basal cell lineage, while active Notch signaling is detected in both the prostate basal and luminal cell lineages. Disrupting the canonical Notch effector Rbp-j impairs the differentiation of prostate basal stem cells and increases their proliferation in vitro and in vivo, but does not affect luminal cell biology.
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Unless otherwise noted, events take place at the InterContinental Berlin. IWF is proud to launch the first World Cornerstone ever to take place in Berlin, with a special behind-the-scenes opening reception at the world-renowned Deutsche Oper Berlin and a live runway show led by German fashion designer Anja Gockel, featuring fashion, dance and song. The Deutsche Oper, though destroyed in World War II, reemerged with a striking s architectural style that symbolizes the renewal of modern Germany. They are all German inventions. There are thousands of others, but many of them are so specialized that the general public will never hear about them—even though they touch the lives of millions, if not billions, of people.