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Breast cancer with estrogen negative tumors

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Dogs that are spayed at a young age have a reduced risk of developing mammary tumors, the canine equivalent of breast cancer. Early spaying reduces levels of estrogen production, leading many veterinarians and scientists to cast estrogen in a negative light when it comes to mammary cancer. But the effects of estrogen on cancer risk in dogs aren't straightforward, according to a new study led by researchers from Penn's School of Veterinary Medicine. While it's clear that spaying dogs greatly minimizes their risk of developing mammary cancer, the findings suggest that the practice may increase the risk of more aggressive cancers.
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Breast Cancer Hormone Receptor Status

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Breast Cancer Hormone Receptor Status | Estrogen Receptor

Some types of breast cancer are affected by hormones, like estrogen and progesterone. The breast cancer cells have receptors proteins that attach to estrogen and progesterone, which helps them grow. Treatments that stop these hormones from attaching to these receptors are called hormone or endocrine therapy. Hormone therapy can reach cancer cells almost anywhere in the body and not just in the breast. It's recommended for women with tumors that are hormone receptor-positive.
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An Overview of Triple-Positive Breast Cancer

And research suggests that hormone-receptor-negative breast cancers may respond better to chemotherapy than hormone-receptor-positive breast cancers do. Depending on the rest of your test results, you also may be able to take another medication called Herceptin chemical name: trastumuzab. Your pathology report will tell you whether or not the breast cancer cells have too many copies of a gene called HER2 or too much of the receptor protein it makes.
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Skip to Content. To help doctors give their patients the best possible care, the American Society of Clinical Oncology ASCO asks its medical experts to develop evidence-based recommendations about specific topics in cancer care. These recommendations are for the treatment of human epidermal receptor 2 HER2 -negative breast cancer that has spread beyond the breast to areas either nearby the breast or to distant parts of the body.
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